CHIP 5 Input Chip 3D
Part number 3200834
The 5 Input Chip 3D 150 µm is a glass microfluidic device designed on the layout described in papers by Jahn (2007) Microfluidic Directed Formation of Liposomes of Controlled Size (DOI: 10.1021/la070051a). The new 3D pore structure enables particle precipitation to occur in the bulk of the fluid avoiding particle-channel wall interaction. The chip is particularly suitable for the controllable formation of a central laminar focused stream sheathed between two or four lateral antisolvent streams. The design allows reproducible diffusive mixing at the two liquid interfaces for polymer particle nanoprecipitation and nanoliposome self-assembly.
Rapid generation of stable focused laminar stream in the middle of the outlet channel.
Possibility to control the thickness of the laminar focused stream by changing the flow rate ratio between the lateral fluids and the central sheathed fluid.
Ideal for producing nanoparticles (e.g. PLGA, liposomes) by antisolvent precipitation.
Circular microchannel profile at the junction for stable stream generation.
Generates highly monodisperse nanoparticles.
Hydrophilic, hydrophobic and fluorophilic versions
Quartz version for improved optical transmission.
Excellent chemical compatibility.
High visibility (excellent access for optics).
Compatible with Dolomite Linear Connectors for quick and reliable fluidic connection.